Mother's milk of all different mammals contain different 'cocktails' of growth factors. These growth factors enhance growth and development of different organs in suckling. Adults consuming whatever milk, always absorb those growth factors too. Cells in adults however, don't need to multiply that fast anymore. And of course cow's-milk-growth factors arenot meant for humans.
Besides stimulating growth of normal
cells, growth factors unfortunately also stimulate growth of cells that have
been damaged by mutagenic substances (from prepared foods, polluted air etc.).
If DNA / RNA has been damaged, this may cause cancer.
Preventing cancer is about
decreasing intake of mutagenic substances (consume as little proteinous
prepared foods), and about preventing absorption of growth factors other than
those from human milk by the suckling. Consume as little prepared food and do
not consume any kind of milk. See diet
but don't I need the
extra calcium ?
No. Fruits already contain all the
calcium you need. Absorbing more calcium may
cause osteoporosis and arteriosclerosis.
Way too many people think it's not
necessary to breastfeed babies for at least the first 1½ years. And too many people think
it is not necessary at all. That's one of the reasons why so many children are
fat and have allergies and 'behavior disorders' nowadays. Formula milk contents
do not, and never ever will meet mother’s milk contents a bit. How dare those
people deny their children essential nutrients and growth regulators ? A baby
is not a play doll and should be offered everything necessary for optimum
physical and mental development. No baby asks to be born. Don’t consider ‘to do
your baby a favor’ through breastfeeding ; it is your duty once you’ve decided
to put your baby on this planet. For women to go “oh no, my breasts will sag”’,
is an absolute turn off.
milk wasn’t that
essential, do you think nature would have bothered to make animals produce it ?
Why do mammals have to
be breastfed after birth ?
Mammals are intelligent creatures.
And to be intelligent, one needs a large brain. But mammal-young grow inside
their mother. If the mammal-young was to fully mature inside its mother, its
head would be too big to pass the pelvis. The more intelligent a specie, the
more the young are born too early.
Humans are the most intelligent, and
relatively, human heads are the biggest. Therefore human babies can only be
born far too early : after 9 instead of the 21 months one might expect from a
specie this size.
The downside of being born too early
is the helplessness of the baby. Human babies are most helpless for being
delivered far too early. Therefore, they lack all the substances that they
would have received directly from maternal blood.
To compensate this loss, the
newborns are fed through mother's milk, containing the same substances :
nutrients, hormones, growth factors and other peptides. These maternal
‘messenger-substances’ activate the immune system, regulate hormone secretion (1)
and ensure an optimum growth process. (2) Therefore, it is extremely
important that every baby receives mother's milk for at least 1½ years (the
“normal” 6 months, plus 'premature-extend' : 21 minus 9 months).
Some of the growth factors, hormones
and peptides in human milk, cow's milk and milk from other mammals :
- bombesine(a neuropeptide) (3)
- GRP (Gastrin-releasing peptide) (4)
- substance P (a neurotransmitter) (5)
- CGRP (calcitonin-gene-related peptide, also a
- IGF-1 (Insulin-like growth factor-1) (6)
- IGF-2 (6)
- EGF (Epidermal growth factor) (7)
- NGF (Nerve growth factor) (8)
- PRP (Prolactin-releasing peptide (9)
- LHRH (or : GnRH, stimulates secretion of LH and FSH)
- progesterone (11)
- peptide YY (12)
- peptide histidine methionine (12)
- neuropeptide Y (stimulating appetite) (13)
- TRH (stimulating TSH secretion) (14) TRH stimulates prolactin- (15) and GH
secretion (16), through T3. (17)
- TSH (stimulating T3- and T4 secretion) (18)
- T3 (Triiodothyronine) (19) T3 increases the
number of estrogenreceptors, increasing estrogen-influence. (20)
- GHRF (Growth-hormone-releasing factor) (21)
GHRF stimulates GH- and (through GH) IGF-1 and –2 secretion (22)
- ACTH (regulating cortisol secretion) (21)
- neurotensine (23)
- cortisol (24)
- insuline (regulating blood-glucose level) (25)
- beta-endorphine (opioid peptide) (26)
- small opioid peptides (see site12)
- benzodiazepine-agonist peptides (neurotransmitters) (27).
Non-babies Consuming Mothers'
Milk from every mammal is mother's
milk, meant for the suckling. All milk therefore contains growth factors,
hormones and other peptides. The reason why every mammal stops drinking
mother's milk at a certain age, is because by then it produces all its own hormones,
growth factors and other peptides. Production, secretion and level of those
substances is regulated through a complex system of interaction. This system is
impaired by absorbing similar substances from drugs, contraceptives etc.
Logically, level of any of these substances is also influenced by absorbing
similar substances from cow’s milk, goat’s milk etc., causing all kinds of
Growth Factors & Cancer
Why does taking testosterone
increase prostate cancer risk ?
How can having cystic breasts
increase breast cancer risk ?
In cystic breasts, breast-cells are
more sensitive to substances stimulating cell-fission, and therefore
cell-reproduction-rate is higher. And by taking testosterone, prostate- and
muscle-cells are more stimulated to reproduce. In tissues where
reproduction-rate is increased, growth of mutated cells is stimulated as well,
By absorbing external growth
factors, tumors can originate. And tumors can become malignant when they, due to a
mutation, start producing more growth factors, stimulating their own
Therefore, tissues sensitive to the
growth factors in milk are susceptible to cancer through consuming milk.
A large number of scientific
investigations have revealed that consuming milk increases prostate cancer-risk
(28), and also breast (29) and lung cancer risk. (in men)
Breast cancer ; Though eight scientific
investigations show that consuming milk increases breast cancer-risk, a
Finnish, a Dutch- and an Argentinean group of scientists claim dairy products protect
against breast cancer. The Dutch say that only fermented dairy products (like
yogurt) and Dutch Gouda cheese are protective. (31) According to
the Finnish only milk does (32) and according to the Argentineans, only
full fat milk does. (33)
Is it a coincidence that the Dutch, Finnish and
Argentineans have large financial interests in exporting dairy products ?
It is true that through fermentation growth factors
are decomposed, explaining why consuming milk does, but consuming yogurt
doesn't increase breast cancer-risk (34).
Lung cancer ; In Japan, in 1996, people consumed
more than 3 times as much cigarettes as in air-clean Norway (37), but in
Norway lung cancer-mortality in men is higher (35). And also in countries
like Russia, UK, France, Canada, USA and Australia less cigarettes are smoked (36),
but lung cancer mortality in men is higher than in Japan (35). In all
these countries more milk is consumed, containing lung cancer-stimulating
Ovary cancer ; Consuming milk increases ovary
cancer-risk, but according to two groups of scientific investigators, skimmed
milk doesn't. (37)
Colon cancer ; One investigation reveals
consuming milk increases colon cancer-incidence (38), another
investigation shows the opposite. (39)
Different growth factors increase
cancer-risk of different tissues. LHRH for example, stimulates secretion of LH
and FSH, regulating secretion of hormones by sex-organs. Therefore, excessive
LHRH, LH and / or FSH can cause ovary- (40),prostate- (41) and
testicle-cancer. (42) Therefore it depends on the susceptibility of
tissues to the specific growth-stimulating influence of growth factors, what
type of cancer will be caused.
Because every human cell is
susceptible to different growth factors, too much of any growth factor can
cause cancer in different tissues ;
Bombesine ; Milk contains both bombesine and GRP
(bombesine-like peptide). (43) Milk-bombesine-level is 3 times higher as
blood-bombesine-level. (12) GRP and bombesine enhance lung cancer (44)
( : Small-Cell Lung Cancer ; only 7% of the patients survives the first 5
years.), breast cancer (45), prostate cancer (46), brain tumors
(47), pancreas cancer (48) and colon cancer. (49)
Substance P ; Substance P (SP) increases
vascular permeability (50) and stimulates histamine secretion (51),
causing allergic reactions. SP can enhance stomach cancer (52), brain
tumors (53) and Small-cell lung cancer. (54)
EGF ; Like IGF, EGF is quite resistant against decomposing
enzymes. (55) EGF enhances breast- (56), prostate- (57),
and pancreas-cancer. (58)
IGF-and IGF-2 are quite resistant against
decomposing enzymes. (59) IGF-1 and -2 both enhance breast- (60),
ovary- (61), lung- (62) and prostate cancer. (63) IGF-1
also enhances colon cancer (64), leukemia (65), and pancreas
cancer. (66) IGF-2 also enhances bladder cancer. (67)
Growth hormone (GH) ; GH enhances prostate- (68),
breast- (69) and pancreas-cancer (70), brain-tumors (71),
bone cancer (72) and leukemia (73).
Prolactin ; To be able to breastfeed, the female body is well
equipped to cope with a temporarily enlarged prolactin production. Man isn't,
and prolactin-producing tumors in men are therefore larger, more active and
Prolactin enhances breast cancer (75), brain
tumors (76), prostate cancer (77) and leukemia (78).
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(1) Staley, M.D. et al, Ratmilk and dietary long arginine 3 insuline-like growth factor 1 promoto intestinal growth of newborn rat pups. Pediatr. Res. 1998 / 44 (4) / 512-518. , Amit, T. et al, Characterisation of prolactin- and growth hormone-binding proteins in milk and their diversity among species. Mol. Cell. Endocrinol. 1997 / 130 (1-2) / 167-180. , Ellis, L.A. et al ,Do milk-borne cytokines and hormones influence neonatal immune cell function ? Journal of Nutrition 1997 / 127 (5-suppl.) / 985-988. , Jiang, Q. et al, Bombesin differentially affects gastric emptying in suckling, weanling and adult rats. J. Pharmacol. Exp. Ther. 1991 / 257 (2) / 603-607. , Smith, S.S. et al, Maternal modulation of infantile ovarian developement and available ovarian luteinising hormone-releasing hormone (LHRH) receptors via milk LHRH. Endocrinology 1984 / 115 (5) / 1973-1983.(2) Meisel, H. ,Biochemical properties of regulatory peptides derived from milk protein.Biopolymers. 1997 / 43 (2) / 119-128.
(3) le Huerou-Luron, I. et al, Source of dietary protein influences kinetics of plasma gut regulatory peptide concentration to feeding in preruminant calves. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 1998 / 119 (3) / 817-824.
(4) Takeyama, M. et al, Enzyme immunoassay of gastrin-releasing peptide (GRP)-like immunoreactivity in milk. Int. J. Pept. Protein Res. 1989 / 34 (1) / 70-74.
(5) Ducroc, R. et al, Immunoreactive substance P and calcitonin-gene-related peptide (CGRP) in rat milk and in human milk and infant formula's. Am. J. Clin. Nutr. 1995 / 62 (3) / 554-558.
(6) Faulkner, A. Insuline-like growth factor 1 concentrations in milk and plasma after growth hormone treatment. Biochem. Soc. Trans. 1998 / 26 (4) / 386. , Silanikove, N. et al, Metabolic and productive response of dairy cows to increased ion supplementation at early lactation in warm weather. J. Dairy Res. 1998 / 65 (4) / 529-543. , Ginjala, V. et al, Determination of transforming growth factor-beta 1 (TGF-beta 1) and insulin-like growth factor-1 (IGF-1) in bovine colostreum samples. J. Immunoassay 1998 / 19 (2-3) / 195-207. , Schober, D.A. et al, Perinatal expression of type 1 IGF receptors in porcine small intestine. Endocrinology 1990 / 126 (2) / 1125-1132.
(7) Murphy, M.S. et al, Growth factors and the gastrointestinal tract. Nutrition 1998 / 14 (10) / 771-774. , Buts, J.P. Bioactive factors in milk. (infrench) Arch. Pediatr. 1998 / 5 (3) / 298-306.
(8) Gaull, G.E. et al, Significance of growth modulators in human milk. Pediatrics 1985 / 75 (pt 2) / 142-145.
(9) Hinuma, S. et al, A prolactin-releasing peptide in the brain. Nature 1998 / 393 (6682) / 272-276.
(10) Smith, S.S. et al, Presence of luteinising hormone-releasing hormone (LHRH) in milk. Endocrinol Exp. 1986 / 20 (2-3) / 147-153. , Koldovsky, O. ,Search for the role of milk borne biologically active peptides for the suckling. J.Nutr. 1989 / 119 (11) / 1543-1551.Nair, R.M. et al, Studies on LHRH and physiological fluid amino acids in human colostreum and milk. Endocrinol. Exp. 1987 / 21 (1) / 23-30.
(11) White, M.E. et al, Milk progesterone concentrations following simultaneous administration of buserelin and cloprostenol in cattle with normal corporal lutea. Can. J. Vet. Res. 1986 / 50 (2) / 285-286. , Dinsmore, R.P. et al, Effect of gonadotropin-releasing hormone on clinical response and fertility in cows with cystyic ovaries ,as related to milk progesterone concentration and days after partarition. J. Am. Vet. Med. Assoc. 1989 / 195 (3) / 327-330.
(12) Berseth, C.I. et al, Postpartum changes in pattern of gastrointestinal regulatory peptides in human milk. Am. J. Clin. Nutr. 1990 / 51 (6) / 985-990.
(13) Flood, J.F. et al, Increased food intake by neuropeptide Y is due to an increased motivation to eat. Peptides 1991 / 12 (6) / 1329-1332.
(14) Amarant, T. et al, Luteinising hormone-releasing hormone and thyrotropin-releasing hormone in human and bovine milk. European Journal of Biochemistry 1982 / 127 (3) / 647-650. , Baram ,T. et al, Gonadotropin-releasing hormone in milk. Science 1977 / 198 (4314) / 300-302.
(15) Koike, K. et al, The pituitary folliculo-stellate cell line TtT/GF augments basal and TRH-induced prolactin secretion by GH3 cells. Life Sci. 1997 / 61 (25) / 2491-2497. , Tyson, J.E. et al, The influence of prolactine secretion on human lactation. J. Clin. Endocrinol. Metab. 1975 / 40 (5) / 764-773.
(16) Grochowska, R. et al, Stimulated growth hormone (GH) release in Friesian cattle with respect to GH genotypes. Reprod. Nutr. Dev. 1999 / 39 (2) / 171-180. , Bourne, R.A. et al, Serum growth hormone concentrations after growth hormone or thyroid-releasing hormone in cows. J. Dairy Sci. 1977 / 60 (10) / 1629-1635.
(17) Chomczinsky, P. et al, Stimulatory effect of thyroid hormone on growth hormone gene expression in a human pituitary cell line. J. Clin. Endocrinol. Metab. 1993 / 77 (1) / 281-285. , Reynolds, A.M. ,The effects of chronic exposure to supraphysiological concentrations of 3,5,3`triiodo-L-thyronine (T3) on cultured GC cells. J. Cell. Physiol. 1991 / 149 (3) / 544-547.
(18) Tenore, A. et al, Thyroidal response to peroral TSH in suckling and weaned rats. Am. J. Physiol. 1980 / 238 (5) / E428-430.
(19) Slebodzinski, A.B. et al, Triiodothyronine (T3) ,insulin and characteristics of 5'-monodiodinase (5'-MD) in mare's milk from partarition to 21 days post-partum. Reprod. Nutr. Dev. 1998 / 38 (3) / 235-244.
(20) Fujimoto, N. et al, Upregulation of the estrogen receptor by triiodothyronine in rat pituitary cell lines. J. Steroid. Biochem. Mol. Biol. 1997 / 61 (1-2) / 79-85.
(21) Koldovsky, O., Search for the role of milk borne biologically active peptides for the suckling. J.Nutr. 1989 / 119 (11) / 1543-1551. , Buts, J.P. Bioactive factors in milk. (in french) Arch. Pediatr. 1998 / 5 (3) / 298-306.
(22) Faulkner, A. ,Insulin-like growth factor concentrations in milk and plasma after growth hormone treatment. Biochem. Soc. Trans. 1998 / 26 (4) / S386. , Baldini, E. et al, In vivo cytokinetic effects of recombinant human growth hormone (rhGH) in patients with advanced breast carcinoma. J. Biol. Regul. Homeost. Agents 1994 / 8 (4) / 113-116. , Scheven, B.A. et al, Effects of recombinant human insulin-like growth factor-1 and -2 (IGF) and growth hormone (GH) on the growth of normal adult human osteoblast-like cells and human osteogenic sarcoma cells. Growth Regul. 1991 / 1 (4) / 160-167. , Hodate, K. et al, Plasma growth hormone, insuline-like growth factor-1, and milk production response to exogenous human growth hormone-releasing factor analogs in dairy cows. Endocrinol. Jpn. 1990 / 37 (2) / 261-273.
(23) Westrom, B.R. et al, Levels of immunoreactive insulin, neurotensin, and bombesin in porcine colostreum and milk. J. Pediatr. Gastroenterol. Nutr. 1987 / 6 (3) / 460-465. , Ehman, R. et al, Bombesin, neurotensin and pro-gamma-melanotropin in immunoreactants in human milk. Regul. Pept. 1985 / 10 (2-3) / 99-105.
(24) Shutt, D.A. et al, Comparison of total and free cortisol in bovine serum and milk colostreum. J. Dairy Sci. 1985 / 68 (7) / 1832-1834.
(25) Vaarala, O. et al, Cow milk feeding induces antibodies to insulin in children -- a link between cow milk and insulin-dependent diabetes mellitus ? Scand. J. Immunol. 1998 / 47 (2) / 131-135. , Slebodzinsky, A.B. et al, Triiodothyronine (T3) ,insulin and characteristics of 5'-monodiodinase (5'-MD) in mare's milk from partarition to 21 days post-partum. Reprod. Nutr. Dev. 1998 / 38 (3) / 235-244. , Westrom, B.R. et al, Levels of immunoreactive insulin, neurotensin, and bombesin in porcine colostreum and milk. J. Pediatr. Gastroenterol. Nutr. 1987 / 6 (3) / 460-465.
(26) Ferrando, T. et al, Beta-endorphin-like and alpha-MSH-like immunoreactivities in human milk. Life Sci. 1990 / 47 (7) / 633-635.
(27) Medina, J.H. et al, Presence of benzodiazepine-like molecules in mammalian brain and milk. Biochem. Biophys. Res. Commun. 1988 / 152 (2) / 534-539.
(28) Schuurman, A.G. et al, Animal products, calcium and protein and prostate cancer risk in The Netherlands Cohort Study. Br. J. Cancer 1999 / 80 (7) / 1107-1113. , Giovannucci E, Nutritional factors in human cancers. Adv. Exp. Med. Biol. 1999 / 472 / 29-42. , Giovanucci, E. ,Dietary influences of 1,25(OH)2 vitamin D in relation to prostate cancer : a hypothesis. Cancer Causes Control. 1998 / 9 (6) / 567-582. , Willet, W.C. ,Nutrition and Cancer. Salud. Publica. Mex. 1997 / 39 (4) / 298-309. , De Stefani, E. et al, Tobacco, alcohol, diet and risk of prostate cancer. Tumori 1995 / 81 (5) / 315-320. , Le Marchand, L. et al, Animal fat consumption and prostate cancer : a prospective study in Hawaii. Epidemiology 1994 / 5 (3) / 276-282. , Talamini, R. et al, Diet and prostate cancer : a case control study in northern Italy. Nutr. Cancer 1992 / 18 (3) / 277-286. , La Vecchia, C. et al, Dairy products and the risk of prostatic cancer. Oncology 1991 / 48 (5) / 406-410. , Mettlin, C. et al, Beta-carotene and animal fats and their relationship to prostate cancer risk. A case control study. Cancer 1989 / 64 (3) / 605-612. , Snowdon, D.A., animal product consumption and mortality because of all causes combined, coronary heart disease, stroke, diabetes, and cancer in Seventh-day Adventists. Am. J. Clin. Nutr. 1988 / 48 (3 suppl.) / 739-748. , Talamini, R. et al, Nutrition, social factors, and prostate cancer in a northern Italian population. Br. J. Cancer 1986 / 53 (6) / 817-821. , Rose, D.P. et al, International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer 1986 / 58 (11) / 2263-2271.
(29) Mannisto, S. et al, Diet and the risk of breast cancer in a case control study : does the threat of disease have an influence on recall bias ? J. Clin. Epidemiol. 1999 / 52 (5) / 429-439. , Outwater, J.L. et al, Dairy products and breast cancer : the IGF-1, estrogen and bGH hypothesis. Med. Hypothesis 1997 / 48 (6) / 453-461. , Gaard, M. et al, Dietary fat and the risk of breast cancer : a prospective study of 25,892 Norwegian women. Int. J. Cancer 1995 / 63 (1) / 13-17. , Decarli, A. et al, Environmental factors and cancer mortality in Italy : correlational exercise. Oncology 1986 / 43 (2) / 116-126. , Rose, D.P. et al, International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption. Cancer 1986 / 58 (11) / 2363-2371. , Shimada, A. et al, Ecological approach to the eating habits and the cancer mortality of Brazilian people. (in het japans) Gan No Rinsho 1986 / 32 (6) / 631-640. , La Vecchia, C. et al, Age at first birth, dietary practises and breast cancer mortality in various Italian regions. Oncology 1986 / 43 (1) / 1-6. , Talamini, R. et al, Social factors, diet and breast cancer in a northern Italian population. Br. J. Cancer 1984 / 49 (6) / 723-729.
(30) Nyberg, F. et al, Dietary factors and risk of lung cancer. Int. J. Cancer 1998 / 78 (4) / 430-436. , Rylander, R. et al, Lung cancer, smoking and diet among Swedish men. Lung Cancer 1996 / 14 (suppl.1) / S75-S83. , Axelsson, G. et al, Dietary factors and lung cancer among men with in west Sweden. Int. J. Epidemiol. 1996 / 25 (1) / 32-39. , Mayne, S.T. et al, Dietary beta-carotene and lung cancer risk in United States non-smokers. J. Natl. Cancer Inst. 1994 / 86 (1) / 33-38. , Goodman, M.T. et al, High fat foods and the risk of lungcancer. Epidemiology 1992 / 3 (4) / 288-299. , Kodama, M. et al, Interrelation between Western type cancers and non-Western type cancers as regards their risk variations in time and space 2. Nutrition and cancer risk. Anticancer Res. 1990 / 10 (4) / 1043-1049. , Mettlin, C. ,Milk drinking, other beverage habits and lung cancer risk. Int. J. Cancer 1989 / 43 (4) / 608-612.
(31) van 't Veer ,P. et al, Consumption of fermentated milkproducts and breast cancer : a case control study in the Netherlands. Cancer Res. 1989 / 49 (14) / 4020-4023.
(32) Jarvinen, R. et al, Diet and breast cancer risk in a cohort of Finnish women. Cancer Lett. 1997 / 114 (1-2) / 251-253. , Knekt, P. et al, Intake of dairy products and the risk of breast cancer. Br. J. Cancer 1996 / 73 (5) / 687-691.
(33) Iscovich, J.M. et al, A case control study of diet and breast cancer in Argentina. Int. J. Cancer 1989 / 44 (5) / 770-776.
(34) Le, M.G. et al, Consumption of dairy products and alcohol in a case-control study of breast cancer. J. Natl. Cancer Inst. 1986 / 77 (3) / 633-636.
(35) WHO.org / health topics / cancer. (internet)
(36) Chapman, S. et al, Changes in adult cigarette consumption per head in 128 countries, 1986-1990. Tobacco Control 1992 / 1 / 281-284.
(37) Webb, P.M. et al, Milk consumption, galactose metabolism and ovarian cancer (Australia) Cancer Causes Control 1998 / 9 (6) / 637-644. , Mettlin, C.J. et al, A case control study of milk-drinking and ovarian cancer risk. Am. J. Epidemiol. 1990 / 132 (5) / 871-876. , Cramer, D.W. ,Lactase persistence and milk consumption as determinants of ovarian cancer risk. Am. J. Epidemiol. 1989 / 130 (5) / 904-910.
(38) Correa, P. ,Epidemiological correlations between diet and cancer frequency. Cancer Res. 1981 / 41 (9 Pt 2) / 3685-3690.
(39) Rosen ,M. et al, Diet and cancer mortality in the counties of Sweden. Am. J. Epidemiol. 1988 / 127 (1) / 42-49.
(40) Maruuchi, T. et al, Effects of gonadotropin-releasing hormone agonist on rat ovarian adenocarcinoma cell lines in vitro and in vivo. Jpn. J. Cancer Res. 1998 / 89 (9) / 977-983. , Kuroda, H. et al, Human chorionic gonadotrophin (hCG) inhibits cisplatin-induced apoptosis in ovarian cancer cells pssibe rle of up-regulation of IGF-1 by hCG. Int. J. Cancer 1998 / 76 (4) / 571-578. , Kurbacher, C.M. et al, Influence of luteinising hormone on cell growth and CA 125 secretion of primary epithelial ovarian carcinomas in vitro. Tumour. Biol. 1995 / 16 (6) / 374-384. , Manetta, A. et al, Inhibition of growth of human ovarian cancer in nude mice by luteinising hormone-releasing hormone antagonist Cetrorelix (SB-75). Fertil. Steril. 1995 / 63 (2) / 282-287.
(41) Reiter, E. et al, Effects of pituitary hormones on the prostate. Prostate 1999 / 38 (2) / 159-165. , Lamharzi, N. et al , Luteinising hormone-releasing hormone (LH-RH) antagonist Cetrorelix inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of IGF-2 in tumors. Regul. Pept. 1998 / 77 (1-3) / 185-192. , Jungwirth, A. et al, Luteinising hormone-releasing hormone (LH-RH) antagonist Cetrorelix (SB-75) and bombesin antagonist RC-3940-2 inhibit the growth of androgen-independent PC-3 prostate cancer in nude mice. Prostate 1997 / 32 (3) / 164-172. , Maezawa, H et al, Potentiating effect of buserelin acetate, an LHRH agonist, on the proliferation of ventral prostatic epithelial cells in testosterone-treated castrated rats. Int. J. Urol. 1997 / 4 (4) / 411-416. , Hsing, A.W. et al, Serological precursers of cancer serum hormones and risk of subsequent prostate cancer. Cancer Epidemiol. Biomarkers Prev. 1993 / 2 (1) / 27-32. , Garde, S. et al, Effect of prostatic inhibiting peptide on prostate cancer cell growth in vitro and in vivo. Prostate 1993 / 7 (2) / 183-194.
(42) Bosland, M.C., Hormonal factors in carcinogenesis of the prostate and testis in humans and in animal models Prg Clin. Biol. Res. 1996 / 394 / 309-352.
(43) Koldovski, O. et al, Milk-borne hormones : possible tools of communication between mother and suckling. Physiol. Res. 1995 / 44 (6) / 349-351. , Koldovsky, O. et al, Hormonally active peptides in human milk. Acta Paediatr. Suppl. 1994 / 402 / 89-93. , Lehy ,T. et al, Promoting effect of bombesin on the cell proliferation in the rat endocrine pancreas during the early post natal period. Regul.Pept. 1990 / 27 (1) / 87-96. , Pollack, P.F. ,Effects of enterally- and parenterally- administrated bombesin on intestinal luminal tryptic activity and protein in the suckling rat. Experienta 1989 / 45 (4) / 385-388. , Lazarus, L.H. et al, An immunoreactive peptide in milk contains bombesin-like bioactivity. Experienta 1986 / 42 (7) / 822-823. , Jahnke, G.D. et al, A bombesin immunoreactive peptide in milk. Proc. Natl. Acad. Sci. U.S.A. 1984 / 81 (2) / 578-582.
(44) Nyeki, O. et al, Synthesis of peptide and pseudopeptide amides inhibiting the proliferation of small-cell and epithelial types of lung carcinoma cells. J. Pept. Sci. 1998 / 4 (8) / 486-495. , Fathi, Z. et al, Bombesin receptor structure and expression in human lung carcinoma cell lines. J. Cell Biochem. Suppl. 1996 / 24 / 237-246. , Yang, H.K. et al, Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines. Lung Cancer 1998 / 21 (3) / 165-175. , Casanueva, F.F. et al, Correlation between the effects of bombesin antagonists on cell proliferation and intracellular calcium concentration in swiss 3T3 and HT-29 cell lines. Proc. Natl. Acad. Sci. U.S.A. 1996 / 93 (4) / 1406-1411. , Tallet, A. et al, Neuropeptides stimulate tyrosine phosphorylation and tyrosinekinase activity in small cell lungcancer cell lines. Peptides 1996 / 17 (4) / 665-673. , Kane, M.A. et al, Isolation of the bombesin / gastrin-releasing peptide receptor from human small cell lung carcinoma NCL-H345 cells. J. Biol. Chem. 1991 / 266 (15) / 9486-9493. , King, R.J. et al, Regulation of lung cell proliferation by polypeptide growth factrs Am. J. Physiol. 1989 / 257 (2 pt 1) / L23-L38. , Sunday, M.E. et al, Gastrin-releasing peptide (mammelian-bombesin) gene expression in health and disease. Lab. Invest.1988 / 59 (1) / 5-24. , Zachary, I. et al, High affinity receptors for peptides of the bombesin family in swiss 3T3 cells. Proc. Natl. Acad. Sci. USA, 1985 / 82 (22) / 7616-7620. , Sporn, M.B. et al, Autocrine growth factors and cancer. Nature 1985 / 313 (6005) / 745-747. , Cuttitta, F. et al, Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer. Life Sci. 1985 / 37 (2) / 105-113. , Moody, T.W. et al, Bombesin-like peptides in small cell lung cancer : biochemical characterization and secretion from a cell line. Life Sci. 1983 / 32 (5) / 487-493. , Erisman, M.D. et al, Human small-cell carcinoma contains bombesin. Proc. Natl. Acad. Sci. USA, 1982 / 79 (7) / 2379-2383. , Wood, S.M. et al ,Bombesin, somatostatin and neurotensin-like immunoreactivity in bronchial carcinoma. J. Clin. Endocrinol. Metab. 1981 / 53 (6) / 1310-1312.
(45) Burns, D.M. et al, Breast cancer cell-associated endopeptidase EC24.11 modulates proliferative response to bombesin. Br. J. Cancer 1999 / 79 (2) / 214-220. , Bold, R.J. et al, Bombesin stimulates in vitro growth of human breast cancer independent of estrogen receptor status. Anticancer Res. 1998 / 18 (16A) / 4051-4056. , Miyazaki, M. et al, Inhibition of growth of MDA-MB-231 human breast cancer xenografts in nude mice by bombesin / gastrin-releasing peptide (GRP) antagonists RC-3940-II and RC-3095. Eur. J. Cancer 1998 / 34 (5) / 710-717. , Nelson, J. et al , Bombesin stimulates proliferation of human breast cancer cells in culture. Br. J. Cancer 1991 / 63 (6) / 933-936. , Giacchetti, S. et al, Characterization ,in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells. Int. J. Cancer 1990 / 46 (2) / 293-298. , Weber, C.J. et al, Gastrin-releasing peptide- ,calcitonin gene-related peptide, and calcitonin-like immuno-reactivity in human breast cyst fluid and
gastrin-releasing peptide-like immunoreactivity in human breast carcinoma cell lines. Surgery 1989 / 106 (6) / 1134-1139 / disc.1139-1140.
(46) Markwalder, R. et al, Gastrin-releasing peptide receptors in the human prostate : relation to neoplastic transformation. Can. Res. 1999 / 59 (5) / 1152-1159. , Festuccia, C. et al, In vitro regulation of pericellular proteolysis in prostatic tumor cells treated with bombesin. Int. J. Cancer 1998 / 75 (3) / 418-431. , Krongrad, A. et al, Endopeptidase 24.11 activity in the human prostate cancer cell lines LNCaP and PPC-1. Urol. Res. 1997 / 25 (2) / 113-116. , Jungwirth ,A. et al, LHRH antagonist Cetrolix (SB-75) and bombesin-antagonist RC-3940-II inhibit the growth of androgen-independent PC-3 prostate cancer in nude mice. Prostate 1997 / 32 (3) / 164-172. , Larran, J. et al, In vitro characterization of bombesin and calcitonin on the proliferation of PC3, DK145 and LNCaP cancer prostatic cell lines. Int. J. Dev. Biol. 1996 / suppl. 1/ 275S-276S. , Aprickian ,A.G. et al, Bombesin specifically induces intracellular calcium mobilization via gastrin-releasing peptide receptors in human prostatic cancer cells. J. Mol. Endocrinol. 1996 / 16 (3) / 297-306. , Bologna, M. et al, Bombesin stimulates growth of human prostatic cancer cells in vitro. Cancer 1989 / 63 (9) / 1714-1720. , Wasilenko, W.J. et al, Effects of the calcium influx inhibitor carboxyamido-triazole on the proliferation and invasiveness of human prostate tumor cell lines. Int. J. Cancer 1996 / 68 (2) / 259-264.
(47) Sharif, M. ,Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic / glial brain tumor-derived cell lines. Int. J. Oncol. 1998 / 12 (2) / 273-286.
(48) Damge, C. ,Effect of the gastrin-releasing peptide antagonist BIM 26226 and lanreotide on a acinar pancreatic carcinoma. Eur. J. Pharmacol. 1998 / 347 (1) / 77-86. , Burghardt, B. et al, Agonists and antagonists of regulatory peptides as tools to study regulation of pancreatic exocrine secretion, cell proliferation and gene expression. Scand. J. Gastroenterol. Suppl. 1998 / 228 / 11-20. , Wang, Q.J. et al, Bombesin may stimulate proliferation of human pancreatic cancer cells through an autocrine pathway. Int. J. Cancer 1996 / 68 (4) / 528-534. , Qin ,Y. et al, Antagonists of bombesin / gastrin-releasing peptide inhibit growth of SW-1990 human pancreatic adenomacarcinoma and production of cyclic AMP. Int. J. Cancer 1995 / 63 (2) / 257-262.
(49) Saurin, J.C. et al, Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isrecol cell lines. Cancer Res. 1999 / 59 (4) / 962-967. , Narayan, S. et al, Specific binding and growth effects of bombesin-related peptides on mouse colon cancer cells in vitro. Can. Res. 1990 / 50 (12) / 6772-6778.
(50) Lembeck, F. et al ,Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation.Arch. Pharmacol. 1979 / 310 (2) / 175-183.
(51) Khare, V.K. et al, The neuropeptide / mast cell secretagogue substance P is expressed in cutaneous melanocytic lesions. J. Cutan. Pathol. 1998 / 25 (1) / 2-10.
(52) Tatsuta, M. et al, Promotion by substance P of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Cancer Lett. 1995 / 96 (1) / 99-103.
(53) Sharif, M. ,Mitogenic signaling by substance P and bombesin-like neuropeptide receptors in astrocytic / glial brain tumor-derived cell lines. Int. J. Oncol. 1998 / 12 (2) / 273-286.
(54) Seckl, M.J. et al, Effect of tyrphostin combined with a substance P-related antagonist on small cell cell lungcancer cell growth in vitro. Eur. J. Cancer 1996 / 32(A) / 342-345. , Orosz, A. et al, New short-chain analogs of a substance P antagonist inhibit proliferation of human small cell lung cancer cells in vitro and in vivo. Int. J. Cancer 1995 / 60 (1) / 82-87.
(55) Shen, W.H. et al, Stability and distribution of orally administered epidermal growth factor in neonatal pigs. Life Sci. 1998 / 63 (10) / 809-820. , Rao, R.K. et al, Bovine milk inhibits proteolytic degradation of epidermal growth factor in human gastric and duodenal lumen. Peptides 1998 / 19 (3) / 495-504. , McCuskey, R.S. et al, Effect of milk-borne epidermal growth factor on the hepatic microcirculation and Kupfer cell function in suckling rats. Biol. Neonate 1997 / 7 (3) / 202-206. , Oguchi, S. et al, Growth factors in breast milk and their effect on gastrointestinal developement. Chang Hua Min Kuo Hsiao Erh Ko I Hsuek Tsa Chih 1997 / 38 (5) 332-337.
(56) Salomon, D.S. et al, Cripto : a novel epidermal growth factor (EGF)-related peptide in mammary gland developement and neoplasia. Bioessays 1999 / 21 (1) / 61-70. , Chou, Y.C. et al, Induction of mammary carcinomas by N-methyl-N-nitrosurea in ovariectomized rats treated with epidermal growth factor. Carcinogenesis 1999 / 20 (4) / 677-684. , Kurtz, A. et al, Local control of mammary gland differentation : mammary-derived growth inhibitor and pleiotrophin. Biochem. Soc. Symp. 1998 / 63 / 51-69. , Taylor, M.R. et al, Lactadherin (formerly BA46) ; a membrane-associated gycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. DNA Cell Biol. 1997 / 16 (7) / 861-869.
(57) Zhau, H.J. et al, Androgen-depressed phenotype in human prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 1996 / 93 (26) / 15152-15157.
(58) Fisher, W.E. et al, Gastrointestinal hormones as potential adjuvant treatment of exocrine pancreatic adenocarcinoma. Int. J. Pancreatol. 1998 / 24 (3) / 169-180. , Robertson, J.F. ,Effect of gastrointestinal hormones and synthetic analogues on the growth of pancreatic cancer. Int. J. Cancer 1995 / 63 (1) / 69-75.
(59) Rao, R.K. et al, Luminal stability of insulin-like growth factor-1 and -2 in developing rat gastrointestinal tract. J. Pediatr. Gastroenterol. Nutr. 1998 / 26 (2) / 179-185.
(60) Parisot, J.P. et al, Altered expression of the insulin-like growth factor-1 receptor in a tamoxifen-resistant human breast cancer cell line. Br. J. Cancer 1999 / 79 (5-6) / 693-700. , Sciacca, L. et al, Insulin receptor activation by insulin-like growth factor-2 in breast cancers : evidence for a new autocrine / paracrine mechanism. Oncogene 1999 / 18 (15) / 2471-2479. , Grothey, A. et al, The role of insuline-like growth factor and its receptor in cell growth transformation, apoptosis, and chemoresistance in solid tumors. J. Cancer Res. Clin. Oncol. 1999 / 125 (3-4) / 166-173. , Perks, C.M. et al, Activation of integrin and ceramide signalling pathways can inhibit the mitogenic effect of insulin-like growth factor-1 (IGF-1) in human breast cancer cell lines. Br. J. Cancer 1999 / 79 (5-6) / 701-706. , de Cupis, A. et al, Responsiveness to hormone, growth factor and drug treatment of a human breast cancer cell line : comparison between early and late cultures. In Vitro Cell Dev. Biol. Anim. 1998 / 34 (10) / 836-843. , Kobari, M. et al, The inhibitory effect of an epidermal growth factor receptor specific tyrokinase inhibitor on pancreatic cancer cell lines was more potent than inhibitory antibodies against the receptors for EGF and IGF-1. Int. J. Pancreatol. 1998 / 24 (2) / 85-95. , Gooch, J.L. et al, Interleukin 4 inhibits growth and induces apoptosis in human breast cancer cells. Cancer Res. 1998 / 58 (18) / 4199-4205. , Choki, I. et al, Osteoblast-derived growth factors enhance adriamycin-cytostasis of MCF-7 human breast cancer cells. Anticancer Res. 1998 / 18 (16A) / 4213-4224. , Jackson, J.G. et al, Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-1, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J. Biol. Chem. 1998 / 273 (16) / 9994-10003. , Westley, B.R. et al, Interactions between the oestrogen and IGF signalling pathways in the control of breast epithelial cell proliferation. Biochem. Soc. Symp. 1998 / 63 / 35-44. , Surmacz, E. et al, Overexpression of insulin receptor substrate 1 (IRS-1) in the human breast cancer cell line MCF-7 induces loss of estrogen requirements for growth and transformation. Clin. Cancer Res. 1995 / 1 (11) / 1429-1436.
(61) Muller, M. et al, Antisense phosphorotiate oligodeoxynucleotide down-regulation of the insulin-like growth factor-1 receptor in ovarian cancer cells. Int. J. Cancer 1998 / 77 (4) / 567-571. , Kuroda, H. et al, Human chorionic gonadotrophin (hCG) inhibits cisplatin-induced apoptosis in ovarian cancer cells : possible role of up-regulation of IGF-1 by hCG. Int. J. Cancer 1998 / 76 (4) / 571-578.
(62) Long, L. et al, Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor. Exp. Cell Res. 1998 / 238 (1) / 116-121.
(63) Untergasser, G. et al, Proliferative disorders of the aging human prostate : involvement of protein hormones and their receptors. Exp. Gerontol. 1999 / 34 (2) / 275-287. , Xu, Z.D. ,Hammerhead ribozyme-mediated cleavage of the human insulin-like growth factor-2 ribonucleic acid in vitro and in prostate cancer cells. Endocrinology 1999 / 140 (5) / 2134-2144. , Marelli, M.M. et al, Luteinizing hormone-releasing hormone agonists interfere with the antagonic activity of the insulin-like growth factor system in androgen-dependent prostate cancer cells. Endocrinology 1999 / 140 (1) / 329-334. , Lamharzi, N. et al, Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DY-145 human androgen-independent prostate carcinoma in nude mice and supresses the levels and mRNA expression of insulin-like growth factor-2 in tumors. Proc. Natl. Acad. Sci. U.S.A. 1998 / 95 (15) / 8864-8868. , Wang, Y.Z. et al, Sex hormone-induced prostatic carcinogenesis in the noble rat : the role of insulin-like growth factor-1 (IGF-1) and vascular endothelial growth factor (VEGF) in the developement of cancer. Prostate 1998 / 35 (3) / 165-177.
(64) Ma, J. et al, Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3. J. Natl. Cancer Inst. 1999 / 91 (7) / 620-625. , Ye, F. et al, Insulin-like growth factor-1 receptors are expressed by the enteroendocrine cell line STC-1 : relationship with proliferation and cholecystokinin expression. Horm. Res. 1998 / 50 (3) / 183-189. , Cats, A. et al, Increased epithelial cell proliferation in the colon of patients with acromegaly. Cancer Res. 1996 / 56 (3) / 523-526.
(65) Frostad, S. et al, In vitro effects of insulin-like growth factor-1 (IGF-1) on proliferation and constitutive cytokine secretion by acute myelogenous leukemia blasts. Eur. J. Haematol. 1999 / 62 (3) / 191-198.
(66) Douzieck, N. et al, Growth effects of regulatory peptides and intracellular signaling routes in human pancreatic cancer cell lines. Endocrine. 1998 / 9 (2) / 171-183. , Flossmann-Kast, B.B. et al, Src stimulates insulin-like growth factor-1 (IGF-1)-dependent cell proliferation by increasing IGF-1 receptor number in human panvreatic carcinoma cells. Cancer Res. 1998 / 58 (16) / 3551-3554.
(67) Li, S. et al, Expression of insulin-like growth factor-2 (IGF-2) in human prostate, breast, bladder and paraganglioma tumors. Cell Tissue Res. 1998 / 291 (3) / 469-479.
(68) Csernus, V.J. et al, Inhibition of growth, product of insulin-like growth factor-2 (IGF-2) ,and expression of IGF-2 mRNA of human cancer cell lines by antagonistic analogs of GHRH in vitro. Proc.Natl. Acad. Sci. U.S.A. 1999 / 96 (6) / 3098-3103. , Lamharzi, N. et al, Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and supresses the levels and mRNA expression of insulin-like growth factor-2 in tumors. Proc. Natl. Acad. Sci. U.S.A. 1998 / 95 (15) / 8864-8868. , Jungwirth, A. et al, Inhibition of in vivo proliferation of androgen-independent prostate cancers by an antagonist of growth hormone-releasing hormone. Br. J. Cancer 1997 / 75 (11) / 1585-1592. , Yano, T. et al, Effect of microcapsules of luteinising hormone-releasing hormone antagonist SB-75 and somatostatin analogue RC-160 on endocrine status and tumor growth in the Dunning R-3327H rat prostate cancer model. Prostate 1992 / 20 (4) / 297-310. , Sinowatz, F. et al, Growth hormone receptor expression in the Dunning R3327 prostatic carcinoma of the rat. Prostate 1991 / 19 (4) / 273-278.
(69) Alama, A. et al, Diethylstilbestrol (DES) and recombinand human growth hormone (rhGH) as modulators of breast cancer proliferative activity. Pharmacol. Res. 1999 / suppl.3 : 7-8. , Fujikawa, T. et al, Inverse effects of 20K and 22K human growth hormones on the growth of T-47D human breast cancer cells in culture and in nude mice. Biochem. Mol. Biol. Int. 1998 / 46 (4) / 719-724. , Outwater, J.L. et al, Dairy products and breast cancer : the IGH-1, estrogen, and bGH hypothesis. Med. Hypothesis 1997 / 48 (6) / 453-461. , Noguchi, S. et al, Inhibitory effect of a somatostatin analogue (SMS201-995) on the growth of androgen-dependent mouse mammary tumor (Shionogi carcinoma 115). Jpn. J. Res. 1993 / 84 (6) / 656-663.
(70) Harrison, L.E. et al, Effect of human growth hormone on human pancreatic carcinoma growth ,protein, and cell cycle kinetics. J. Surg. Res. 1996 / 61 (2) / 317-322.
(71) Connors, M.H. et al, Expansion and shrinkage of central nervous system tumor coinciding with human growth hormone therapy : case report. Neurosurgery 1996 / 39 (6) / 1243-1245 / disc. 1245-1246. , Cheung, N.W. et al, Somatostatin-14 and its analog octreotide exert a cytostatic effect on GH3 rat pituitary tumor cell proliferation via a transient G0/G1 cell cycle block. Endocrinology 1995 / 136 (8) / 3619-3623.
(72) Slootweg, M.C. et al, Growth hormone activity is stimulated by insulin-like growth factor binding protein-5 in rat osteocarcoma cells. Growth Regul. 1996 / 6 (4) / 238-246.
(73) Baker, D.L. et al, Late leukemic relapse 10 years from diagnosis in a child on recombinant human growth hormone. Pediatr. Hematol. Oncol. 1993 / 10 (1) / 55-62. , Tedeschi, B. et al, Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone. Hum. Genet. 1993 / 91 (5) / 459-463. , Estrov, Z. et al, Human growth hormone and insulin-like growth factor-1 enhance the proliferation of human leukemic blasts. J. Clin. Oncol. 1991 / 9 (3) / 394-399.
(74) Delgrange, E. et al, Sex related differences in the growth of prolactinomas : a clinical and proliferation marker study. J. Clin. Endocrinol. Metab. 1997 / 82 (7) / 2102-2107.
(75) Vonderhaar, B.K. ,Prolactin :The forgotten hormone of human breast cancer. Pharmacol. Ther. 1998 / 79 (2) / 169-178 , Das, R. et al, Involvement of SHC, GRB2, SOS and RAS in prolactin signal transduction in mammary epithelial cells. Oncogene 1996 / 13 (6) / 1139-1145. , Mershon, J. et al, Prolactin is a local growth factor in rat mammary tumors. Endocrinology 1995 / 136 (8) / 3619-3623. , Ginsberg, E. et al, Prolactin secretion by human breast cancer cells. Cancer Res. 1995 / 55 (12) / 2591-2595. , Fuh, G. et al, Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines. J. Biol. Chem. 1995 / 270 (22) / 13133-13137.
(76) Asano, K. et al, The relationship between cell proliferation activity and secretory activity in pituitary adenoma -- a revieuw of 63 cases. (in japans). No To Shinkei 1996 / 48 (6)/ 543-549.
(77) Leav, I. et al, Prolactin receptor expression in the developing human prostate and in hyperplastic, dysplastic, and neoplastic lesions. Am. J. Pathol. 1999 / 154 (3) / 863-870. , Horti, J. et al, A phase 2 study of bromocriptine in patients with androgen-independent prostate cancer. Oncol. Rep. 1998 / 5 (4) / 893-896. , Franklin, R.B. et al, Prolactin regulation of mitochondrial aspartate aminotransferase and proteinkinase C. Moll. Cell. Endocrinol. 1997 / 127 (1) / 19-25. , Janssen, T. et al, In vitro characterization of prolactin-induced effects on proliferation in the neoplastic LNCaP, DU145, and PC3 models of the human prostate. Cancer 1996 / 77 (1) / 144-149. , Janssen, T. et al, Organ culture of human tissue as study model of hormonal and pharmalogical regulation of benign prostatic hyperplasia and of prostatic cancer. (frans) Acta. Urol. Belg. 1995 / 63 (1) / 7-14. , Oliver, R.T. et al, New directions with hormone therapy in prostate cancer : possible benefit from blocking prolactin and use of hormone treatment intermittently in combination with immunotherapy. Eur. J. Cancer 1995 / 31A (6) / 859-860. , Rana, A. et al, A case for synchronous reduction of testicular androgen ,adrenal androgen and prolactin for the treatment of advanced carcinoma of the prostate. Eur. J. Cancer 1995 / 31A (6) / 871-875.
(78) Matera, L. et al, Prolactin is an autocrine growth factor for the Jurkat human T-leukemic cell line. J. Neuroimmunol. 1997 / 79 (1) / 12-21.